Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Insulin-like growth factor I preserves renal function postoperatively

S C Franklin1, M Moulton, G A Sicard

  • 1George M. O'Brien Kidney and Urological Diseases Center, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

The American Journal of Physiology
|February 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Benchmarking a Center of Excellence in Vascular Surgery: Using Acute Physiology and Chronic Health Evaluation II to Validate Outcomes in a Tertiary Care Institute.

Vascular and endovascular surgery·2023
Same author

A mutation in the voltage-gated sodium channel gene associated with pyrethroid resistance in Latin American Aedes aegypti.

Insect molecular biology·2007
Same author

Long-term engraftment following transplantation of pig pancreatic primordia into non-immunosuppressed diabetic rhesus macaques.

Xenotransplantation·2007
Same author

Abdominal aortic aneurysm repair in high-risk and elderly patients.

The Journal of cardiovascular surgery·2003
Same author

Verrucous carcinoma of the foot: a review and report of two cases.

The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons·2002
Same author

Endovascular abdominal aortic aneurysm repair in 144 patients: correlation of aneurysm size, proximal aortic neck length, and procedure-related complications.

Journal of vascular and interventional radiology : JVIR·2001

Insulin-like growth factor-I (IGF-I) may help prevent kidney dysfunction after major surgeries. This study found a lower incidence of renal decline in patients receiving IGF-I compared to placebo.

Area of Science:

  • Nephrology
  • Endocrinology
  • Surgical Complications

Background:

  • Surgery involving the suprarenal aorta or renal arteries poses a risk of postoperative renal failure.
  • Deterioration of renal function is a significant concern in high-risk surgical patients.

Purpose of the Study:

  • To evaluate the efficacy of insulin-like growth factor-I (IGF-I) in preventing postoperative renal dysfunction.
  • To assess IGF-I's safety and tolerability in patients undergoing high-risk surgery.

Main Methods:

  • A double-blind, randomized, placebo-controlled trial involving 54 high-risk patients.
  • Patients received either IGF-I (100 microg/kg subcutaneously every 12 h for 6 doses) or placebo postoperatively.
  • Renal dysfunction was defined as a reduction in glomerular filtration rate (creatinine clearance) over 72 hours.

Related Experiment Videos

Main Results:

  • No patients developed acute renal failure postoperatively in either group.
  • A lower proportion of patients receiving IGF-I experienced a decline in renal function (22%) compared to the placebo group (33%).
  • IGF-I was well tolerated, with no significant differences in hospital stay, ICU stay, intubation, dialysis, or mortality.

Conclusions:

  • IGF-I demonstrates feasibility and potential utility in reducing postoperative renal dysfunction in high-risk surgical patients.
  • Further research is warranted to confirm these findings and establish IGF-I as a standard therapeutic option.