Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nitric oxide and pregnancy

S M Sladek1, R R Magness, K P Conrad

  • 1Magee-Womens Research Institute and Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pennsylvania 15213, USA.

The American Journal of Physiology
|February 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vascular actions of relaxin: nitric oxide and beyond.

British journal of pharmacology·2016
Same author

Ovine fetal renal development impacted by multiple fetuses and uterine space restriction.

Journal of developmental origins of health and disease·2013
Same author

Pregnancy, programming and preeclampsia: gap junctions at the nexus of pregnancy-induced adaptation of endothelial function and endothelial adaptive failure in PE.

Current vascular pharmacology·2013
Same author

Suppression of protein phosphatase 2 differentially modulates VEGF- and FGF2-induced signaling in ovine fetoplacental artery endothelial cells.

Placenta·2009
Same author

Altered global gene expression in first trimester placentas of women destined to develop preeclampsia.

Placenta·2008
Same author

Proteasomal activity in placentas from women with preeclampsia and intrauterine growth restriction: implications for expression of HIF-alpha proteins.

Placenta·2008
Same journal

Blood coagulation in fish.

The American journal of physiology·2011
Same journal

Renal tubular reabsorption, metabolic utilization and isomeric fractionation of lactic acid in the dog.

The American journal of physiology·2010
Same journal

The inactivation of placental toxin by human serum.

The American journal of physiology·2010
Same journal

Adrenal function following ovariectomy in the rat.

The American journal of physiology·2010
Same journal

Capillary permeability; perfusion of frog and guinea pig hind limbs.

The American journal of physiology·2010
Same journal

Evaluation of protective measures against sunburn.

The American journal of physiology·2010
See all related articles

Nitric oxide (NO) aids vasodilation in normal pregnancy but its role in preeclampsia is debated. Research explores NO

Area of Science:

  • Reproductive biology
  • Maternal-fetal medicine
  • Physiology

Background:

  • Nitric oxide (NO) is a key signaling molecule with diverse physiological roles.
  • Its involvement in pregnancy, particularly in vasodilation and blood flow regulation, is under investigation.
  • The role of NO in hypertensive disorders of pregnancy, such as preeclampsia, remains controversial.

Purpose of the Study:

  • To review the contribution of nitric oxide (NO) to maternal systemic vasodilation during pregnancy.
  • To examine NO's role in regulating uterine and fetoplacental blood flow.
  • To assess NO's involvement in uterine quiescence and its potential deficiency in preeclampsia.

Main Methods:

  • Literature review of studies on nitric oxide (NO) and pregnancy.

Related Experiment Videos

  • Analysis of data from animal models (rats, sheep) and human studies.
  • Examination of nitric oxide synthase (NOS) activity and expression in maternal and fetoplacental tissues.

    • Main Results:

    • NO contributes to systemic vasodilation in normal pregnancy, but its role varies by species and vascular bed.
    • Evidence suggests impaired NO-mediated relaxation in preeclampsia, possibly due to receptor defects.
    • Increased endothelial NOS activity in uterine arteries during pregnancy is noted, but its vasodilatory role is unconfirmed.
    • Basal NO production in the placenta contributes to low fetoplacental vascular resistance; placental NOS status in preeclampsia is debated.
    • Uterine NOS activity decreases at term, and exogenous NO relaxes the myometrium, but endogenous NO's role in quiescence is unproven.

    Conclusions:

    • Nitric oxide (NO) plays a role in normal pregnancy vasodilation and fetoplacental blood flow.
    • Its contribution to preeclampsia pathophysiology is uncertain, with potential defects in signaling pathways.
    • Further research is needed to confirm the role of endogenous NO in uterine quiescence during pregnancy.