Effect of dietary DL-ethionine on growth and liver metabolism

The effects of DL-ethionine, given in the diet or by injection, on growth, hepatic glycogen and lipids, and the activities of some cytoplasmic NAD-linked dehydrogenases and NADPH-producing enzymes were investigated. 2. Growth virtually ceased after feeding ethionine for 2 d. 3. Ethionine induced an accumulation of lipid, decreased the activities of malic enzyme and isocitrate dehydrogenase and increased the activity of lactate dehydrogenase. 4. The concentration of glycogen in the liver of ethionine-fed chickens increased for 3 d in spite of a decrease in food intake, but then decreased.