Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Binocular saccadic eye movements in multiple sclerosis

J P Flipse1, C S Straathof, J Van der Steen

  • 1Department of Physiology, Faculty of Medicine, Erasmus University Rotterdam, The Netherlands.

Journal of the Neurological Sciences
|May 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CIDP With and Without Monoclonal Gammopathy of Undetermined Significance (MGUS): Comparison of Clinical Phenotype, Diagnostic Features, and Treatment Response.

Journal of the peripheral nervous system : JPNS·2026
Same author

Guillain-Barré Syndrome Disability Scale.

Journal of the peripheral nervous system : JPNS·2025
Same author

Impact of COVID-19 disease and vaccination on dermatological immune-mediated inflammatory diseases atopic dermatitis, psoriasis, and vitiligo: a Target2B! substudy.

The Journal of dermatology·2025
Same author

Knowledge gaps in diagnosing chronic polyneuropathy: Review of national guidelines.

Journal of the peripheral nervous system : JPNS·2024
Same author

Reply to the Letter to the Editor "Do corticosteroids aggravate pure motor chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)?" by Kokubun N. et al.

Journal of the peripheral nervous system : JPNS·2024
Same author

Oral ribose supplementation in dystroglycanopathy: A single case study.

JIMD reports·2024
Same journal

Distinguishing drug-target effects from natural lipid variation and incorporating imaging outcomes in Mendelian randomisation studies of multiple sclerosis.

Journal of the neurological sciences·2026
Same journal

Long-term social cognitive impairment after ischemic stroke: Frequency and association with lesion volume and location in an exploratory pilot study.

Journal of the neurological sciences·2026
Same journal

Subjective cognitive decline among U.S. Cancer survivors, 2017-2024: Prevalence, cancer-specific patterns, and associated factors.

Journal of the neurological sciences·2026
Same journal

Comment on "Comparative impact of mental and cardiovascular comorbidities on adverse outcomes in people with MS".

Journal of the neurological sciences·2026
Same journal

Comment on "Efficacy and safety of conventional immunosuppressant therapies in elderly patients with Neuromyelitis optica spectrum disorder: A target trial emulation study".

Journal of the neurological sciences·2026
Same journal

Increasing incidence of varicella-zoster virus meningitis in Japan, 2011-2022.

Journal of the neurological sciences·2026
See all related articles

Researchers developed a new method to detect internuclear ophthalmoplegia (INO) in multiple sclerosis (MS) patients by analyzing saccadic eye movements. This technique improves sensitivity for identifying sub-clinical INOs, aiding in earlier diagnosis and management of MS-related eye conditions.

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Neurology

Background:

  • Internuclear ophthalmoplegia (INO) is an eye movement disorder often associated with multiple sclerosis (MS).
  • Current methods for detecting INO may lack sensitivity, particularly for sub-clinical cases.
  • Abnormal binocular saccadic eye movements are key indicators of neurological conditions affecting eye coordination.

Purpose of the Study:

  • To enhance the sensitivity of detecting abnormal binocular saccadic eye movements, specifically INO, in patients with multiple sclerosis (MS).
  • To differentiate between clinically manifest INO, sub-clinical INO, and normal eye movement patterns in MS patients.

Main Methods:

  • Binocular recording of 10 and 20-degree saccades using scleral sensor coils in 10 healthy controls and 26 MS patients.

Related Experiment Videos

  • Analysis of peak velocities and accelerations of saccades, focusing on adducting and abducting eye movements.
  • Calculation of interocular ratios of peak accelerations and velocities to assess binocular coordination.

    • Main Results:

    • Patients with manifest INO exhibited reduced peak velocities and accelerations, especially during adduction.
    • Interocular ratios of peak acceleration to velocity provided a sharper distinction between normal subjects and INO patients.
    • Sub-clinical INOs were identified in 5 MS patients based on elevated interocular ratios, distinct from 14 patients with normal ratios.

    Conclusions:

    • The acceleration of the adducting eye is significantly reduced in patients with INO.
    • Interocular comparison of binocular saccade pairs, particularly the acceleration ratios, is a sensitive method for identifying INO in MS.
    • This approach can detect sub-clinical INOs, improving diagnostic capabilities for neurological eye movement disorders in MS.