Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cognitive function in amyotrophic lateral sclerosis

K Abe1, H Fujimura, K Toyooka

  • 1Department of Neurology, Osaka University Medical School, Suita, Japan.

Journal of the Neurological Sciences
|May 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential Cross Section and Photon-Beam Asymmetry for the γ[over →]p → π^{-}Δ^{++}(1232) Reaction at Forward π^{-} Angles for E_{γ}=1.5-2.95  GeV.

Physical review letters·2018
Same author

Interference Effect between ϕ and Λ(1520) Production Channels in the γp→K^{+}K^{-}p Reaction near Threshold.

Physical review letters·2016
Same author

Molecular dynamics analysis on wetting and interfacial properties of water-alcohol mixture droplets on a solid surface.

The Journal of chemical physics·2015
Same author

Molecular dynamics analysis of multiphase interfaces based on in situ extraction of the pressure distribution of a liquid droplet on a solid surface.

The Journal of chemical physics·2014
Same author

Purification and genetic control of α-pheromone-inactivating glycoproteins in the yeast Saccharomyces cerevisiae.

Current genetics·2013
Same author

Prostacyclin promotes oligodendrocyte precursor recruitment and remyelination after spinal cord demyelination.

Cell death & disease·2013
Same journal

Distinguishing drug-target effects from natural lipid variation and incorporating imaging outcomes in Mendelian randomisation studies of multiple sclerosis.

Journal of the neurological sciences·2026
Same journal

Long-term social cognitive impairment after ischemic stroke: Frequency and association with lesion volume and location in an exploratory pilot study.

Journal of the neurological sciences·2026
Same journal

Subjective cognitive decline among U.S. Cancer survivors, 2017-2024: Prevalence, cancer-specific patterns, and associated factors.

Journal of the neurological sciences·2026
Same journal

Comment on "Comparative impact of mental and cardiovascular comorbidities on adverse outcomes in people with MS".

Journal of the neurological sciences·2026
Same journal

Comment on "Efficacy and safety of conventional immunosuppressant therapies in elderly patients with Neuromyelitis optica spectrum disorder: A target trial emulation study".

Journal of the neurological sciences·2026
Same journal

Increasing incidence of varicella-zoster virus meningitis in Japan, 2011-2022.

Journal of the neurological sciences·2026
See all related articles

Cognitive impairment in amyotrophic lateral sclerosis (ALS) is linked to frontal lobe pathology. This study found a spectrum of cognitive decline, from significant impairment to normal function, correlating with frontal lobe changes in ALS patients.

Area of Science:

  • Neuroscience
  • Neurology

Background:

  • Cognitive dysfunction is increasingly recognized in amyotrophic lateral sclerosis (ALS).
  • The underlying mechanisms of cognitive impairment in ALS are not fully understood.
  • Frontal lobe function is a key area of interest for ALS-related cognitive changes.

Purpose of the Study:

  • To investigate the pathogenesis of cognitive dysfunction in ALS patients.
  • To correlate cognitive performance with neuroimaging and neuropathological findings in the frontal lobe.

Main Methods:

  • Neuropsychological testing was performed on 26 ALS patients and 26 healthy controls, with a focus on frontal lobe functions.
  • Magnetic resonance imaging (MRI) and single-photon emission computed tomography (SPECT) were used to assess frontal lobe structure and function.

Related Experiment Videos

  • Cluster analysis classified patients into subgroups, and neuropathological examination was conducted on six patients.

    • Main Results:

    • ALS patients were categorized into three groups based on cognitive performance; Groups 1 and 2 showed significantly lower scores than Group 3 and controls.
    • Groups 1 and 2 exhibited frontal lobe atrophy on MRI and reduced frontal SPECT uptake, more pronounced in Group 1.
    • Neuropathology in Group 1 revealed frontal lobe spongy degeneration and neuronal loss, while Group 3 showed no significant frontal pathology.

    Conclusions:

    • A continuum of cognitive disability exists in ALS patients, related to frontal lobe pathology.
    • Inattention and executive dysfunction in ALS appear to evolve in parallel with the progression of frontal lobe pathological changes.
    • Findings suggest frontal lobe integrity is crucial for maintaining cognitive function in ALS.