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Pathologic laughter after unilateral stroke

J S Kim1

  • 1Department of Neurology, University of Ulsan, Asan Medical Center, Song-pa, Seoul, South Korea.

Journal of the Neurological Sciences
|May 1, 1997
PubMed
Summary
This summary is machine-generated.

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Unilateral strokes, particularly subcortical ones, can cause pathological laughter. This uncontrollable laughter, often delayed, may involve complex brain mechanisms beyond simple motor release.

Area of Science:

  • Neurology
  • Neuroscience
  • Cerebrovascular Diseases

Background:

  • Pathological laughter is typically associated with widespread or bilateral brain damage.
  • Its occurrence following a unilateral stroke is rare and less understood.

Observation:

  • This study examined 13 patients with unilateral stroke-induced pathological laughter.
  • Laughter was excessive, unmotivated, uncontrollable, often occurring during speech initiation, and sometimes accompanied by emotional lability.
  • A latency period between stroke onset and laughter manifestation was common.

Findings:

  • 12 patients had ischemic strokes and one had a hemorrhagic stroke.
  • Lesions were predominantly in subcortical areas: lenticulocapsular (8), pontine base (3), thalamocapsular (1), and cortical-subcortical (1).

Related Experiment Videos

  • Specific lesion sites included the basal ganglia and internal capsule/corona radiata.

    • Implications:

    • Unilateral subcortical strokes can be a cause of pathological laughter.
    • The delayed onset of symptoms suggests complex neural mechanisms may underlie this condition, potentially involving more than just motor release.
    • Further research is needed to elucidate the precise pathways involved in stroke-related pathological laughter.