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Related Experiment Videos

Cyclosporine in glomerular disease

J A Mowry1, E T McCarthy

  • 1Division of Pediatric Nephrology, Oregon Health Sciences University, Portland 97201-3042, USA.

Seminars in Nephrology
|November 1, 1996
PubMed
Summary

Cyclosporine effectively treats steroid-dependent nephrotic syndrome in children and adults, inducing remission and allowing corticosteroid reduction. However, its efficacy is less pronounced in steroid-resistant cases.

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Area of Science:

  • Nephrology
  • Immunology
  • Pharmacology

Background:

  • Cyclosporine, an immunosuppressive agent, was introduced in 1981 for renal transplantation.
  • Its application expanded to various glomerular disorders due to immunomodulating effects.
  • Focus is on immune-mediated glomerular diseases, particularly idiopathic nephrotic syndrome.

Purpose of the Study:

  • To review the efficacy and safety of cyclosporine in glomerular diseases.
  • To evaluate its role in pediatric and adult idiopathic nephrotic syndrome.
  • To discuss its potential benefits in recurrent nephrotic syndrome and other glomerular conditions.

Main Methods:

  • Review of clinical studies and data on cyclosporine use in glomerular diseases.
  • Analysis of treatment outcomes in steroid-dependent and steroid-resistant nephrotic syndrome.
  • Examination of effects on corticosteroid reduction and patient metabolism.

Main Results:

  • Cyclosporine induces remission in a significant proportion of steroid-dependent nephrotic syndrome patients.
  • Success rates are less encouraging in steroid-resistant nephrotic syndrome.
  • Allows for corticosteroid dose reduction, benefiting growth and metabolism.

Conclusions:

  • Cyclosporine is a valuable therapeutic option for steroid-dependent nephrotic syndrome.
  • Its role in steroid-resistant nephrotic syndrome requires further investigation.
  • Potential benefits in recurrent nephrotic syndrome and other glomerular diseases warrant consideration.

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