Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inhibiting inflammatory cytokines

D C Kluth1, A J Rees

  • 1Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, Scotland.

Seminars in Nephrology
|November 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adhesion of Escherichia coli under flow conditions reveals potential novel effects of FimH mutations.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2016
Same author

2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides.

Arthritis and rheumatism·2012
Same author

Accurate method for the measurement of small wedge angles.

Applied optics·2010
Same author

Depletion of cells of monocyte lineage prevents loss of renal microvasculature in murine kidney transplantation.

Transplantation·2008
Same author

Pro-resolution properties of macrophages in renal injury.

Kidney international·2007
Same author

A glass foreign body in the knee joint mistaken for ACL avulsion: an unusual case.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·2006
Same journal

Current Options for Kidney Protection: Are Renin-Angiotensin System Inhibitors Still Relevant?

Seminars in nephrology·2026
Same journal

Proposed Role for Quantitative Podocyturia as a Clinical Marker of Systemic Endothelial Injury: Implications for Cardiovascular Disease and Longevity.

Seminars in nephrology·2026
Same journal

Kidney Protection Options in 2025: Are Renin-Angiotensin System Inhibitors Still Needed?

Seminars in nephrology·2026
Same journal

From Nephron Number to Global Health.

Seminars in nephrology·2026
Same journal

Chronic Kidney Disease Progression Mechanisms: Why They Matter in an Era of Novel Kidney Protective Therapies.

Seminars in nephrology·2026
Same journal

Of Diuretics, Transporters, and Mechanisms of Hypertension.

Seminars in nephrology·2026
See all related articles

Anti-inflammatory cytokines like IL-4, IL-6, IL-10, and IL-13 show promise in treating acute glomerulonephritis. These cytokines may reduce inflammation and prevent kidney failure by counteracting pro-inflammatory signals.

Area of Science:

  • Nephrology
  • Immunology
  • Molecular Biology

Background:

  • Acute glomerulonephritis is a significant cause of kidney dysfunction and failure.
  • Inflammation, regulated by pro- and anti-inflammatory cytokines, is central to this condition.
  • Key pro-inflammatory cytokines include Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF).

Purpose of the Study:

  • To review the role of anti-inflammatory cytokines in acute glomerulonephritis.
  • To highlight recent research on IL-4, IL-6, IL-10, and IL-13 in renal disease models.
  • To explore novel therapeutic strategies targeting cytokine pathways.

Main Methods:

  • Literature review of existing research on anti-inflammatory cytokines in renal disease models.
  • Analysis of cytokine activities in modulating inflammatory responses in the kidney.

Related Experiment Videos

  • Focus on Interleukin-4 (IL-4), Interleukin-6 (IL-6), Interleukin-10 (IL-10), and Interleukin-13 (IL-13).

    • Main Results:

    • Anti-inflammatory cytokines can decrease the synthesis of pro-inflammatory cytokines like IL-1 and TNF.
    • These cytokines can enhance the production of natural antagonists to pro-inflammatory mediators.
    • Evidence suggests these cytokines can deactivate inflammatory cells, such as macrophages, in the renal environment.

    Conclusions:

    • Anti-inflammatory cytokines present a promising therapeutic avenue for acute glomerulonephritis.
    • Targeting IL-4, IL-6, IL-10, and IL-13 may offer a novel strategy to manage renal dysfunction and failure.
    • Further research in renal disease models supports the potential clinical application of these cytokines.