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Updated: Sep 2, 2026

An ELISA Based Binding and Competition Method to Rapidly Determine Ligand-receptor Interactions
Published on: March 14, 2016
Interleukin-1 receptor antagonism
D J Nikolic-Paterson1, H Y Lan, R C Atkins
1Department of Nephrology, Monash Medical Centre, Clayton, Victoria, Australia.
Abstract:
Interleukin-1 (IL-1) is a pro-inflammatory cytokine that exerts a wide range of biological effects. The recently identified IL-1 receptor antagonist (IL-1ra) has provided a tool for blocking IL-1 activity in vivo, leading to a detailed understanding of the role of this cytokine in the inflammatory response. The importance of IL-1 production in glomerulonephritis has been shown by the ability of IL-1ra treatment to suppress the induction and progression of experimental crescentic glomerulonephritis. Although further studies are required, IL-1ra treatment is an attractive adjunct therapy for patients with progressive glomerulonephritis.
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