Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Estimation of chemoreflex loop gain using pseudorandom binary CO2 stimulation

S D Ghazanshahi1, M C Khoo

  • 1Department of Electrical Engineering, California State University, Fullerton 92634, USA. sghazanshahi@ccvax.fullerton.edu

IEEE Transactions on Bio-Medical Engineering
|May 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autonomic and metabolic effects of OSA in childhood obesity.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2010
Same author

Sickle cell disease: selected aspects of pathophysiology.

Clinical hemorheology and microcirculation·2010
Same author

"Optimal" application of ventilatory assist in Cheyne-Stokes respiration: a simulation study.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2007
Same author

Dynamics of heart rate control in obstructive sleep apnea: a minimal model.

Advances in experimental medicine and biology·2001
Same author

Respiratory instability and variability: why is respiration such a mess? A workshop summary.

Advances in experimental medicine and biology·2001
Same author

Cardiac autonomic control in obstructive sleep apnea: effects of long-term CPAP therapy.

American journal of respiratory and critical care medicine·2001

This study introduces a new method to measure chemoreflex control loop gain (LG) using CO2 inhalation tests. The technique offers a quick and effective way to assess respiratory control stability.

Area of Science:

  • Physiology
  • Respiratory Control
  • Systems Biology

Background:

  • Chemoreflex control loop gain (LG) is crucial for respiratory stability.
  • Traditional methods for assessing chemoresponsiveness can be time-consuming and complex.
  • Understanding LG variations is important for conditions affecting respiratory control, such as during sleep-wake state changes.

Purpose of the Study:

  • To develop and validate a novel method for estimating chemoreflex control loop gain (LG).
  • To assess the utility of this method for quantitative assessment of respiratory control stability.
  • To provide a rapid (<10 min) alternative to traditional chemoresponsiveness tests.

Main Methods:

  • Utilized a pseudorandom binary sequence of inhaled CO2 (0-5%) to elicit ventilatory responses.

Related Experiment Videos

  • Computationally separated the direct CO2 effect from the chemoreflex-mediated ventilation.
  • Estimated LG in the 0.01-0.03 Hz frequency range, relevant to periodic breathing.

    • Main Results:

    • The developed method showed strong correlations between predicted and estimated LG magnitudes.
    • LG magnitude estimates were consistent with traditional methods using simulated and experimental data.
    • LG phase estimates exhibited higher variability compared to small-signal analysis predictions.

    Conclusions:

    • The novel method provides a reliable estimation of chemoreflex control loop gain (LG).
    • This technique is potentially more practical for assessing respiratory control stability than existing methods.
    • The method's speed and simplicity make it suitable for clinical applications, particularly during sleep-wake state transitions.