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Severe cystitis associated with tiaprofenic acid
M L Crawford1, P C Waller, S M Wood
1Medicines Control Agency, London, UK.
British Journal of Urology
|April 1, 1997
Summary
Tiaprofenic acid, a non-steroidal anti-inflammatory drug (NSAID), is frequently linked to severe cystitis. Promptly stopping this NSAID can lead to recovery from urinary symptoms.
Area of Science:
- Pharmacovigilance
- Urology
- Drug Safety
Background:
- Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for pain and inflammation.
- Urinary disorders are potential adverse drug reactions (ADRs) associated with NSAID use.
- Tiaprofenic acid is an NSAID prescribed in the UK.
Purpose of the Study:
- To review UK spontaneous reports of urinary disorders linked to tiaprofenic acid and other NSAIDs.
- To contextualize these reports within the usage patterns of these drugs in the UK.
Main Methods:
- Analysis of suspected ADR reports of urinary disorders associated with tiaprofenic acid and other NSAIDs.
- Data sourced from the UK's spontaneous ADR reporting scheme.
Main Results:
- Between 1982 and August 1994, 69 cases of cystitis and 32 related urinary symptoms were reported for tiaprofenic acid.
- Only eight cases of cystitis were reported for all other NSAIDs combined.
- Recovery typically occurred within weeks after prompt discontinuation of tiaprofenic acid; however, some patients required surgery.
Conclusions:
- Tiaprofenic acid can cause severe cystitis, presenting symptoms similar to interstitial cystitis.
- A comprehensive drug history is crucial for diagnosing unexplained chronic cystitis.
- Immediate cessation of tiaprofenic acid is recommended for patients experiencing urinary symptoms.