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Related Experiment Videos

Severe cystitis associated with tiaprofenic acid

M L Crawford1, P C Waller, S M Wood

  • 1Medicines Control Agency, London, UK.

British Journal of Urology
|April 1, 1997
PubMed
Summary

Tiaprofenic acid, a non-steroidal anti-inflammatory drug (NSAID), is frequently linked to severe cystitis. Promptly stopping this NSAID can lead to recovery from urinary symptoms.

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Area of Science:

  • Pharmacovigilance
  • Urology
  • Drug Safety

Background:

  • Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for pain and inflammation.
  • Urinary disorders are potential adverse drug reactions (ADRs) associated with NSAID use.
  • Tiaprofenic acid is an NSAID prescribed in the UK.

Purpose of the Study:

  • To review UK spontaneous reports of urinary disorders linked to tiaprofenic acid and other NSAIDs.
  • To contextualize these reports within the usage patterns of these drugs in the UK.

Main Methods:

  • Analysis of suspected ADR reports of urinary disorders associated with tiaprofenic acid and other NSAIDs.
  • Data sourced from the UK's spontaneous ADR reporting scheme.

Main Results:

  • Between 1982 and August 1994, 69 cases of cystitis and 32 related urinary symptoms were reported for tiaprofenic acid.
  • Only eight cases of cystitis were reported for all other NSAIDs combined.
  • Recovery typically occurred within weeks after prompt discontinuation of tiaprofenic acid; however, some patients required surgery.

Conclusions:

  • Tiaprofenic acid can cause severe cystitis, presenting symptoms similar to interstitial cystitis.
  • A comprehensive drug history is crucial for diagnosing unexplained chronic cystitis.
  • Immediate cessation of tiaprofenic acid is recommended for patients experiencing urinary symptoms.

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