Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clonality of multiple meningiomas

A P Stangl1, R Wellenreuther, D Lenartz

  • 1Institute of Neuropathology and Neurosurgery Clinic, University Hospital of Bonn, Germany.

Journal of Neurosurgery
|May 1, 1997
PubMed
Summary

Most multiple meningiomas stem from a single cell's mutation in the neurofibromatosis type 2 (NF2) gene. Tumor cells likely spread through cerebrospinal fluid to form new, clonal meningiomas.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents.

Cell death & disease·2026
Same author

GLI1/2-altered mesenchymal tumors: a study of 8 cases expanding the clinicopathological and molecular spectrum including an upstream PTCH1-inactivating mutation.

Virchows Archiv : an international journal of pathology·2025
Same author

Is surgeon annual case volume related with intra and postoperative complications after ventral hernia repair? Authors' reply.

Hernia : the journal of hernias and abdominal wall surgery·2024
Same author

Is surgeon annual case volume related with intra and postoperative complications after ventral hernia repair? Uni- and multivariate analysis of prospective registry-based data.

Hernia : the journal of hernias and abdominal wall surgery·2024
Same author

Thrombus or tumor? A case report of a rare sarcoma entity: intimal sarcoma of the pulmonary arteries.

Molecular biology reports·2024
Same author

Isocitrate-dehydrogenase-mutant lower grade glioma in elderly patients: treatment and outcome in a molecularly characterized contemporary cohort.

Journal of neuro-oncology·2023

Area of Science:

  • Oncology
  • Genetics
  • Neurosurgery

Background:

  • Multiple meningiomas can develop without clear anatomical connections.
  • The neurofibromatosis type 2 (NF2) gene is frequently inactivated in meningiomas.

Purpose of the Study:

  • To investigate the genetic origin of multiple meningiomas.
  • To determine if multiple meningiomas arise from a single clone or independent events.

Main Methods:

  • DNA analysis of 39 meningiomas from 12 patients.
  • Single-strand conformation polymorphism and DNA sequencing of the NF2 gene.
  • Analysis of constitutional DNA to exclude inherited NF2 mutations.

Main Results:

  • NF2 gene mutations were found in 10 of 12 patients.

Related Experiment Videos

  • In 6 patients, all tumors shared identical NF2 mutations, indicating clonal origin.
  • Four patients with multiple lesions had clonal meningiomas; two had distinct mutations.

    • Conclusions:

    • The majority of multiple meningiomas with NF2 mutations are of somatic and clonal origin.
    • Spread of tumor cells via cerebrospinal fluid is the likely mechanism for multiple tumor development.