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Initial experience with collagen-filled Guglielmi detachable coils for endovascular treatment of experimental
I Szikora1, A K Wakhloo, L R Guterman
1Stroke Research Institute, Department of Neurosurgery, State University of New York at Buffalo, School of Medicine and Biomedical Sciences 14209, USA.
Purpose:
To evaluate the effectiveness of Guglielmi detachable coils (GDCs) filled with collagen threads in the permanent treatment of experimental aneurysms.
Methods:
Seventeen side-wall aneurysms were surgically constructed in the canine common carotid artery; six were treated with conventional GDCs and 11 with collagen-filled GDCs. One aneurysms was removed at 1 week, the others were studied by digital subtraction angiography for a period of 8 to 12 weeks. Longitudinal sections of all aneurysms were examined by light microscopy.
Results:
Angiograms obtained throughout the follow-up period showed no significant difference between aneurysms treated with conventional GDCs and those treated with collagen-filled GDCs. Light microscopy revealed a dense meshwork of newly formed collagen and fibroblasts near the collagen-filled GDCs, whereas a loose cellular meshwork surrounded the conventional GDCs at 8 and 12 weeks after treatment.
Conclusion:
Collagen threads within GDCs do not noticeably improve angiographic treatment of experimental aneurysms; however, these threads did induce local proliferation of fibroblasts and production of collagen within the aneurysmal cavities.