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Related Experiment Videos

Time-dependent gestational diabetes screening values

M Cetin1, A Cetin

  • 1Department of Obstetrics and Gynecology, Cumhuriyet University Hospital, Sivas, Turkey.

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics
|March 1, 1997
PubMed
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Adjusting gestational diabetes mellitus screening cut-offs based on meal timing improves test efficiency. New values reduce false positives and the need for further oral glucose tolerance testing.

Area of Science:

  • Obstetrics and Gynecology
  • Endocrinology
  • Clinical Chemistry

Background:

  • Gestational diabetes mellitus (GDM) screening is crucial for maternal and fetal health.
  • Current GDM screening protocols may be improved for accuracy and efficiency.
  • The timing of a patient's last meal can influence glucose challenge test results.

Purpose of the Study:

  • To evaluate the effectiveness of adjusted glucose challenge test (GCT) cut-off values based on the time since the last meal for GDM screening.
  • To determine if these adjusted cut-offs can enhance screening accuracy and patient management.

Main Methods:

  • A study involving 274 non-diabetic pregnant women (26-28 weeks gestation) was conducted.
  • Participants underwent a 50g glucose challenge test (GCT).

Related Experiment Videos

  • Results were analyzed using a standard cut-off (140 mg/dl) and proposed meal-time adjusted cut-offs (148 mg/dl, 142 mg/dl, 150 mg/dl for <2h, 2-3h, >3h fasting, respectively).

    • Main Results:

    • The adjusted cut-off values decreased the positive GCT rate from 15.7% to 11.3%.
    • The positive predictive value of the GCT increased from 27.3% to 32.3% with the new cut-offs.
    • 274 women completed the study, providing robust data for analysis.

    Conclusions:

    • The time elapsed since the last meal significantly impacts 50g GCT results.
    • Implementing meal-time adjusted cut-offs can improve the efficiency of GDM screening.
    • These refined cut-offs are expected to reduce the number of patients unnecessarily referred for a 3-hour oral glucose tolerance test (OGTT).