Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Improved endothelial function with angiotensin-converting enzyme inhibitors

¹Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville 32610, USA.

The American Journal of Cardiology

|March 6, 1997

Summary

Angiotensin-converting enzyme (ACE) inhibitors improve endothelial function, which may explain their cardiovascular benefits. Studies show ACE inhibitors like quinapril enhance coronary vasomotor function and show potential for improving microvascular blood flow.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Arterial stiffness assessment in coronary microvascular dysfunction and heart failure with preserved ejection fraction: An initial report from the WISE-CVD continuation study.

American heart journal plus : cardiology research and practice·2024

Same author

Coronary atheroma burden predicts flow reserve in women with ischemia and nonobstructive coronary artery disease.

American heart journal plus : cardiology research and practice·2024

Same author

Cold Pressor Testing and Sympathetic Nervous System Contribution to Ischemia with No Obstructive Coronary Artery Disease: Results from the Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction Project.

American heart journal plus : cardiology research and practice·2022

Same author

Genome-wide association study identifies pharmacogenomic loci linked with specific antihypertensive drug treatment and new-onset diabetes.

The pharmacogenomics journal·2016

Same author

Five-year stroke rate in women with signs and symptoms of ischemia undergoing coronary angiography: a retrospective study from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE).

JRSM open·2015

Same author

Association of KCNJ1 variation with change in fasting glucose and new onset diabetes during HCTZ treatment.

The pharmacogenomics journal·2012

Area of Science:

Cardiology
Vascular Biology
Pharmacology

Background:

Plasma renin activity is associated with coronary events.
Angiotensin-converting enzyme (ACE) inhibitors reduce coronary risk.
Endothelial dysfunction is a key factor in cardiovascular outcomes.

Purpose of the Study:

To investigate the role of ACE inhibitors in improving endothelial function.
To assess the impact of ACE inhibitors on vascular relaxation and atherosclerosis progression.
To evaluate quinapril's effect on coronary endothelium-dependent vasomotor function.

Main Methods:

Review of clinical trials and animal models.
Analysis of endothelial function surrogate outcomes.
The Trial on Reversing ENdothelial Dysfunction (TREND) study using quinapril.

Related Experiment Videos

Main Results:

ACE inhibitors restore endothelium-mediated vascular relaxation in atherosclerosis models.
The TREND trial showed improved coronary endothelium-dependent vasomotor function with quinapril.
Quinapril treatment trended toward increased microvascular blood flow response.

Conclusions:

Improved endothelial function likely contributes to the cardiovascular benefits of ACE inhibitors.
ACE inhibitors, such as quinapril, demonstrate positive effects on vascular function.
Ongoing research will further assess ACE inhibitors' impact on clinical coronary risk and plaque progression.