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Crystal structures of heterochiral peptides. Part II. tert-Boc-valyl-D-alanyl-leucyl-alanyl methoxide
V Nagarajan1, V Pattabhi, A Johnson
1Department of Crystallography and Biophysics, University of Madras, India.
Abstract:
Crystal structure of a heterochiral peptide, viz. Boc-Val1-D-Ala2-Leu3-Ala4-OMe with a D chiral residue in the second position of a sequence, has been determined [a = 40.44(1), b = 4.887(5), c = 15.381(5) A, beta = 109.6(1)degrees, space group C2, Z = 4, R = 0.11]. The peptide is in a parallel beta-sheet structure terminated by a distinct local bend. The structure is established by N-H...O as well as C alpha-H...O hydrogen bonds. The contiguous C alpha-H...O hydrogen bond observed in this structure is an unique observation.