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Related Experiment Videos

Clinical experience with echo-enhanced transcranial Doppler and duplex imaging

F Ries1

  • 1Department of Neurology, University Clinic, Bonn, Germany.

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
|April 1, 1997
PubMed
Summary

Levovist, an ultrasound contrast agent, enhances transcranial Doppler (TCD) and transcranial color-coded duplex sonography (TCCD) imaging. This improves visualization of intracranial vasculature in patients with poor baseline signals, aiding cerebrovascular disease diagnosis safely.

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Area of Science:

  • Neuroimaging
  • Ultrasound Technology
  • Vascular Imaging

Background:

  • Transcranial Doppler (TCD) and transcranial color-coded duplex sonography (TCCD) are safe ultrasound neuroimaging techniques.
  • The skull bone limits signal penetration, challenging image quality and interpretation for TCD and TCCD.
  • Intracranial vascular assessment is crucial for diagnosing cerebrovascular diseases.

Purpose of the Study:

  • To evaluate the utility of Levovist, an intravenous ultrasound echo-enhancement agent, for improving TCD and TCCD studies.
  • To assess Levovist's efficacy in patients with insufficient or absent native ultrasound signals.
  • To determine optimal Levovist concentrations for diagnostic enhancement.

Main Methods:

  • European phase II and III clinical trials were conducted.

Related Experiment Videos

  • Levovist was administered intravenously at 200, 300, or 400 mg/ml concentrations.
  • TCD and TCCD studies were repeated after Levovist administration in patients with poor baseline signals.

    • Main Results:

    • Concentrations of 300 to 400 mg/ml Levovist were sufficient for echo enhancement.
    • 300 mg/ml was often preferred in phase II studies for superior imaging with minimal side effects.
    • Levovist significantly improved the diagnostic utility of TCD and TCCD without compromising patient safety.

    Conclusions:

    • Echo enhancement with Levovist facilitates routine clinical investigation of intracranial vascular anatomy.
    • Levovist enables visualization of small vessels, venous circulation, and perfusion data in patients with no native signal.
    • Levovist-enhanced TCD and TCCD offer a safe and effective method for neurovascular assessment.