Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease in myocardial polyamine concentration in rats with myocardial infarction

S Hasegawa1, M Nakano, K Hamana

  • 1Second Department of Internal Medicine, University of Gunma, Maebashi, Japan.

Life Sciences
|January 1, 1997
PubMed
Summary

Cardiac polyamines protect the heart. Myocardial infarction in rats led to decreased polyamines and impaired ornithine decarboxylase activity, suggesting reduced heart protection and increased vulnerability.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alterations in the metabolic and cardiorespiratory response to exercise in Huntington's Disease.

Parkinsonism & related disorders·2018
Same author

Monitoring of circulating tumour-associated DNA as a prognostic tool for oral squamous cell carcinoma.

British journal of cancer·2005
Same author

Accumulation of spermidine/spermine N1-acetyltransferase and alternatively spliced mRNAs as a delayed response of HeLa S3 cells following X-ray irradiation.

International journal of radiation biology·2004
Same author

Polyamine distribution profiles in newly validated genera and species within the Flavobacterium-Flexibacter-Cytophaga-Sphingobacterium complex.

Microbios·2001
Same author

Proposal of the genus Sphingomonas sensu stricto and three new genera, Sphingobium, Novosphingobium and Sphingopyxis, on the basis of phylogenetic and chemotaxonomic analyses.

International journal of systematic and evolutionary microbiology·2001
Same author

Polyamine distribution profiles in the eighteen genera phylogenetically located within the Flavobacterium-Flexibacter-Cytophaga complex.

Microbios·2001

Area of Science:

  • Cardiovascular Research
  • Molecular Cardiology
  • Biochemistry

Background:

  • Cardiac polyamines are believed to protect the myocardium from stressors.
  • Sympathetic nerve activation is thought to regulate cardiac polyamine levels.

Purpose of the Study:

  • To investigate polyamine concentrations in the non-infarcted myocardium following myocardial infarction.
  • To explore the relationship between polyamine levels, ornithine decarboxylase activity, and sympathetic function post-myocardial infarction.

Main Methods:

  • Assessment of polyamine concentrations in rat myocardium post-myocardial infarction.
  • Measurement of cardiac catecholamine levels.
  • Evaluation of myocardial ornithine decarboxylase activity.

Related Experiment Videos

Main Results:

  • A significant decrease in myocardial polyamine content was observed in non-infarcted regions by day 3 post-myocardial infarction.
  • Cardiac catecholamine concentration decreased by day 1 post-myocardial infarction.
  • Myocardial ornithine decarboxylase activity also decreased in non-infarcted regions, correlating with reduced polyamine levels.

Conclusions:

  • Decreased polyamine concentrations after myocardial infarction are linked to functional sympathetic nerve denervation.
  • Reduced polyamine levels in the non-infarcted region may contribute to myocardial vulnerability following infarction.