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Dynamically stabilized pores in bilayer membranes

J D Moroz1, P Nelson

  • 1Department of Physics and Astronomy, University of Pennsylvania, Philadelphia 19104, USA. moroz@student.physics.upenn.edu

Biophysical Journal
|May 1, 1997
PubMed
Summary
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Large pores in artificial lipid bilayers were created and stabilized by a novel feedback mechanism. This study explains their sudden closure and offers a method to measure pore line tension in membranes.

Area of Science:

  • Biophysics
  • Materials Science
  • Membrane Biophysics

Background:

  • Artificial lipid bilayer vesicles are crucial models for cell membranes.
  • Electroporation can create transient pores in these vesicles.
  • The stability and closure dynamics of large pores present a theoretical challenge.

Purpose of the Study:

  • To explain the mechanism behind the dynamic stabilization of large pores in lipid bilayers.
  • To quantitatively describe the sudden closure of these pores.
  • To demonstrate a method for accurately measuring pore line tension.

Main Methods:

  • Theoretical modeling of pore stabilization using a feedback mechanism.
  • Analysis of pore closure dynamics as a tangent bifurcation.

Related Experiment Videos

  • Application of the model to experimental data from Zhelev and Needham.

    • Main Results:

    • A novel feedback mechanism dynamically stabilizes large quasistable pores in lipid bilayers.
    • Sudden pore closure is quantitatively explained as a tangent bifurcation.
    • The experiment provides an accurate method for determining pore line tension.

    Conclusions:

    • The study elucidates the physics governing the transient stability of large pores in artificial membranes.
    • The findings offer a new perspective on membrane mechanics and pore formation.
    • Accurate measurement of pore line tension is achievable using this experimental approach.