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Are differentiated human T helper cells reversible?

R A Seder¹, C Prussin

¹Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. 20892, USA. rseder@nih.gov

International Archives of Allergy and Immunology

|May 1, 1997

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Cytokines can alter established immune cells, potentially reversing Th1/Th2 polarization. This finding offers new strategies for treating autoimmune and allergic diseases.

Area of Science:

Immunology
Cellular immunology

Background:

Cytokines regulate immune responses, influencing T helper cell differentiation (Th1/Th2).
The plasticity of established Th1 and Th2 cells in disease pathogenesis remains a critical question.

Purpose of the Study:

To investigate if cytokines can alter the phenotype of established Th1 and Th2 cells.
To explore the potential for immune manipulation in established diseases.

Main Methods:

Established murine Th1 and Th2 cell lines were treated with specific cytokines.
Intracellular cytokine staining was performed to analyze cytokine production at a single-cell level.

Main Results:

Cytokines were shown to alter the cytokine production profiles of established Th1 and Th2 cells.

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Single-cell analysis confirmed changes in cytokine expression on an individual cell basis.

Conclusions:

Established Th1 and Th2 cell populations are plastic and can be modulated by cytokine treatment.
These findings suggest novel therapeutic approaches for manipulating immune responses in established allergic and autoimmune conditions.