Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Photostimulation with caged neurotransmitters using fiber optic lightguides

D W Godwin¹, D Che, D M O'Malley

¹Department of Neurobiology and Behavior, State University of New York at Stony Brook, New York 11794-5230, USA. dgodwin@bgsm.edu

Journal of Neuroscience Methods

|April 25, 1997

Summary

Researchers developed a novel fiberoptic method for precise light-activated drug delivery, enhancing control over caged neurotransmitter release for neuroscience research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Study on the correlation between high expression of FHL1 in gastric cancer cells and cisplatin resistance].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2026

Same author

Rucaparib maintenance for newly diagnosed advanced ovarian cancer: interim overall survival, progression-free survival, and safety at 5 years of follow-up from the phase III ATHENA-MONO/GOG-3020/ENGOT-ov45 study.

Annals of oncology : official journal of the European Society for Medical Oncology·2025

Same author

Targeting the future: Antibody-Drug Conjugates (ADCs) in platinum-sensitive ovarian cancer in the post-PARP era.

Annals of oncology : official journal of the European Society for Medical Oncology·2025

Same author

Niraparib first-line maintenance therapy in patients with newly diagnosed advanced ovarian cancer: final overall survival results from the PRIMA/ENGOT-OV26/GOG-3012 trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2024

Same author

Inclusion, diversity, equity, and access (IDEA) in gynecologic cancer clinical trials: A joint statement from GOG foundation and Society of Gynecologic Oncology (SGO).

Gynecologic oncology·2023

Same author

Association between transforming growth factors-β and matrix metalloproteinases in the aqueous humor and plasma in myopic patients.

Journal francais d'ophtalmologie·2022

Area of Science:

Neuroscience
Biochemistry
Optics

Background:

'Caged' neurotransmitters are light-sensitive molecules activated by specific wavelengths.
Current methods involve complex light delivery systems via microscope optics.
Existing techniques offer limited spatial and temporal control over drug delivery.

Purpose of the Study:

To introduce a simpler and more flexible method for caged neurotransmitter delivery.
To demonstrate the feasibility of fiberoptic lightguides for precise uncaging.
To enhance spatial and temporal resolution in neuroactive substance application.

Main Methods:

Utilized finely tapered fiberoptic lightguides for light delivery.
Tested the method across ex vitro, in vitro, and in vivo experimental setups.

Related Experiment Videos

Manipulated light wavelength, intensity, and timing to control uncaging.

Main Results:

Demonstrated feasibility and flexibility of the fiberoptic approach.
Achieved precise control over the degree and timing of neurotransmitter uncaging.
Showcased enhanced spatial and temporal resolution compared to traditional methods.
Enabled delivery of labile substances like nitric oxide via photosensitive precursors.

Conclusions:

Fiberoptic lightguides offer a significant advancement for caged compound applications.
This method provides superior control over neuroactive substance delivery.
The technique expands possibilities for both in vitro and in vivo neuroscience research.