Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

In vitro platelet function in controlled ovarian hyperstimulation cycles

G Richard-Davis1, V Montgomery-Rice, E F Mammen

  • 1Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA.

Fertility and Sterility
|May 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of molecular driver mutations in recurrence of early-stage laryngeal cancer following narrow field definitive radiotherapy.

Oral oncology reports·2026
Same author

Accelerating domain-aware electron microscopy analysis using deep learning models with synthetic data and image-wide confidence scoring.

npj computational materials·2025
Same author

Therapeutic Treatment With OLX-07010 Inhibited Tau Aggregation and Ameliorated Motor Deficits in an Aged Mouse Model of Tauopathy.

Journal of neurochemistry·2025
Same author

Great ape surveys and the implications of long-term monitoring in the Djéké Triangle, Republic of Congo.

Primates; journal of primatology·2024
Same author

Understanding Global Access to Topical Onychomycosis Therapy: A Systematic Review and Meta-Analysis.

Mycoses·2024
Same author

Immune biomarker evaluation of sequential tyrosine kinase inhibitor and nivolumab monotherapies in renal cell carcinoma: the phase I TRIBE trial.

Immuno-oncology technology·2024
Same journal

More Than Cycles: Rethinking Cancer Surveillance in PMOS.

Fertility and sterility·2026
Same journal

Fresh vs. frozen donor oocytes: which strategy best serves patients in contemporary assisted reproductive technology?

Fertility and sterility·2026
Same journal

From fetal life to adulthood: cardiometabolic health of offspring conceived by assisted reproductive technologies, a systematic review.

Fertility and sterility·2026
Same journal

Uterus-Sparing Laparoscopic Reversal of Complete Non-Puerperal uterine Inversion: A rare Case and Challenging Procedure!

Fertility and sterility·2026
Same journal

Minimally Invasive, Fertility-Sparing Surgical Management of Multiple Bilateral Ovarian Dermoid Cysts.

Fertility and sterility·2026
Same journal

Preconception dietary patterns in association with live birth and pregnancy loss: a couples-based approach.

Fertility and sterility·2026
See all related articles

Elevated estrogen (E2) during controlled ovarian hyperstimulation (COH) did not significantly alter in vitro platelet function, suggesting no increased risk of blood clots. This finding is crucial for understanding hormonal effects on thrombosis risk.

Area of Science:

  • Reproductive endocrinology
  • Hematology
  • Thrombosis research

Background:

  • Controlled ovarian hyperstimulation (COH) involves elevated endogenous estradiol (E2) levels.
  • Platelet function is critical in hemostasis and thrombosis.
  • Understanding E2's impact on platelet function during COH is essential for patient safety.

Purpose of the Study:

  • To investigate the effects of supraphysiological endogenous E2 levels on in vitro platelet function in women undergoing COH.
  • To assess potential alterations in platelet aggregation and adenosine triphosphate (ATP) release.
  • To evaluate the association between E2 levels and markers of platelet activation.

Main Methods:

  • Study included women undergoing COH and women with normal ovulatory cycles.

Related Experiment Videos

  • Serum E2, von Willebrand factor antigen (vWF-Ag), and platelet aggregation/ATP release were measured.
  • Platelet aggregation was assessed using adenosine diphosphate (ADP), collagen (COL), and arachidonic acid (AA).

    • Main Results:

    • Estradiol levels were significantly elevated during COH.
    • No significant changes were observed in overall in vitro platelet function (Thrombostat 4000, aggregation with ADP/AA, ATP release).
    • A notable increase in collagen-induced platelet aggregation was observed, potentially linked to elevated vWF-Ag levels.

    Conclusions:

    • Supraphysiological E2 levels during COH do not appear to significantly impair in vitro platelet function.
    • The observed increase in collagen-induced aggregation warrants further investigation but does not suggest a heightened risk for arterial thromboembolism.
    • Findings indicate a potentially safe profile regarding platelet-mediated thrombosis risk in COH patients.