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Growth in the diabetic child
1Department of Pediatrics, University of California, Davis Medical Center, Sacramento, USA.
Pediatric Clinics of North America
|April 1, 1997
Insights
Insulin is crucial for growth during puberty, and its absence causes endocrine issues. Understanding insulin
Area of Science:
- Endocrinology
- Growth Hormone (GH) and Insulin-like Growth Factor-I (IGF-I) Axis
- Adolescent Metabolism
Background:
- Insulin plays a vital role in the GH:IGF-I axis, essential for normal development.
- Absence of insulin can lead to significant endocrine disturbances, especially during puberty.
- Rapid growth during the prediabetic phase is noted and may represent a risk factor.
Purpose of the Study:
- To explore the role of insulin in the GH:IGF-I axis during puberty.
- To investigate the implications of insulin deficiency on adolescent growth and final height.
- To understand the impact of hepatic insulin on IGF-I bioactivity in diabetic adolescents.
Main Methods:
- Review of existing literature on insulin, GH:IGF-I axis, and puberty.
- Analysis of growth patterns in prediabetic and diabetic adolescents.
- Examination of the relationship between hepatic insulin and IGF-I bioactivity.
Main Results:
- Insulin absence causes major endocrine disturbances, particularly impacting pubertal growth.
- Final height is more closely related to gender and age of onset than specific growth factors.
- Hepatic insulin significantly influences IGF-I bioactivity, with implications for diabetic adolescents.
Conclusions:
- Insulin is indispensable for normal pubertal development and the GH:IGF-I axis.
- Prediabetic growth spurts warrant attention as potential risk factors.
- Hepatic insulin's role in IGF-I bioactivity is critical for managing diabetes in adolescents.
Abstract:
Insulin has an important role in the GH:IGF-I axis, and its absence leads to major endocrine disturbances, particularly during puberty. Rapid growth in the prediabetic phase occurs and may be a risk factor. Final height reflects gender and the age of onset more than specific growth factors. The influence of hepatic insulin on IGF-I bioactivity has important implications in diabetic adolescents.