Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Growth in the diabetic child

M H Connors1

  • 1Department of Pediatrics, University of California, Davis Medical Center, Sacramento, USA.

Pediatric Clinics of North America
|April 1, 1997
PubMed
Summary

Insulin is crucial for growth during puberty, and its absence causes endocrine issues. Understanding insulin

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pubertal growth in IDDM is determined by HbA1c levels, sex, and bone age.

Diabetes care·1998
Same author

Expansion and shrinkage of central nervous system tumor coinciding with human growth hormone therapy: case report.

Neurosurgery·1996
Same author

Diminished thyroxine-binding globulin in pubertal diabetic children.

Diabetes care·1996
Same author

"Chordoid" meningeal tumors in young individuals with peritumoral lymphoplasmacellular infiltrates causing systemic manifestations of the Castleman syndrome. A report of seven cases.

Cancer·1988
Same author

Transient neonatal 'athyreosis' resulting from thyrotropin-binding inhibitory immunoglobulins.

Pediatrics·1986
Same author

Headaches and growth arrest in an adolescent.

Hospital practice (Office ed.)·1985

Area of Science:

  • Endocrinology
  • Growth Hormone (GH) and Insulin-like Growth Factor-I (IGF-I) Axis
  • Adolescent Metabolism

Background:

  • Insulin plays a vital role in the GH:IGF-I axis, essential for normal development.
  • Absence of insulin can lead to significant endocrine disturbances, especially during puberty.
  • Rapid growth during the prediabetic phase is noted and may represent a risk factor.

Purpose of the Study:

  • To explore the role of insulin in the GH:IGF-I axis during puberty.
  • To investigate the implications of insulin deficiency on adolescent growth and final height.
  • To understand the impact of hepatic insulin on IGF-I bioactivity in diabetic adolescents.

Main Methods:

  • Review of existing literature on insulin, GH:IGF-I axis, and puberty.
  • Analysis of growth patterns in prediabetic and diabetic adolescents.
  • Examination of the relationship between hepatic insulin and IGF-I bioactivity.

Main Results:

  • Insulin absence causes major endocrine disturbances, particularly impacting pubertal growth.
  • Final height is more closely related to gender and age of onset than specific growth factors.
  • Hepatic insulin significantly influences IGF-I bioactivity, with implications for diabetic adolescents.

Conclusions:

  • Insulin is indispensable for normal pubertal development and the GH:IGF-I axis.
  • Prediabetic growth spurts warrant attention as potential risk factors.
  • Hepatic insulin's role in IGF-I bioactivity is critical for managing diabetes in adolescents.

Related Experiment Videos