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Developing circadian rhythmicity. Basic and clinical aspects

S A Rivkees1

  • 1Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA.

Pediatric Clinics of North America
|April 1, 1997
PubMed
Summary

The circadian timing system influences human behavior and physiology from fetal development. Understanding its maturation and disorders is crucial for clinical care, with treatments like light therapy available.

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Area of Science:

  • Chronobiology
  • Developmental Biology
  • Physiology

Background:

  • The circadian timing system is a fundamental regulator of human behavior and physiology.
  • Circadian clock function initiates during fetal development and matures postnatally.
  • Photic regulation of circadian phase is evident at birth in primates.

Purpose of the Study:

  • To review the development and clinical relevance of the circadian timing system.
  • To highlight recognized circadian system disorders and their treatments.

Main Methods:

  • Review of existing scientific literature on circadian biology and development.
  • Synthesis of evidence regarding circadian system maturation and its impact on physiology.
  • Identification of current therapeutic interventions for circadian rhythm disorders.

Main Results:

  • Circadian system development begins in utero, with progressive maturation of day-night rhythms in activity and hormone secretion between 1-3 months postnatally.
  • Recognized circadian disorders include clock disorders and issues with circadian phase entrainment.
  • Effective treatments such as light therapy and melatonin are available.

Conclusions:

  • The circadian timing system plays a critical role throughout human development.
  • Clinical recognition and management of circadian system disorders are advancing.
  • Circadian biology is expected to become increasingly integral to clinical practice.

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