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Related Experiment Videos

Sclerosing mesenteritis, mesenteric panniculitis and mesenteric lipodystrophy: a single entity?

T S Emory1, J M Monihan, N J Carr

  • 1Department of Hepatic and Gastrointestinal Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.

The American Journal of Surgical Pathology
|April 1, 1997
PubMed
Summary

Sclerosing mesenteritis (SM), mesenteric panniculitis (MP), and mesenteric lipodystrophy (ML) are likely variants of a single clinical entity. Histologic features often overlap, suggesting "sclerosing mesenteritis" as the most appropriate diagnostic term.

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Area of Science:

  • Gastroenterology
  • Pathology

Background:

  • Mesenteric lipodystrophy (ML), mesenteric panniculitis (MP), and sclerosing mesenteritis (SM) are distinct conditions.
  • Histologic evaluation of these conditions involves grading fibrosis, inflammation, and fat necrosis.

Purpose of the Study:

  • To determine if ML, MP, and SM represent distinct entities or variants of a single condition.
  • To evaluate clinical subgroups and features that may differentiate these conditions.

Main Methods:

  • Review of 84 cases coded as ML, MP, or SM.
  • Grading of fibrosis, inflammation, and fat necrosis in mesenteric tissues.
  • Evaluation of clinical, demographic, and gross features.

Main Results:

  • No significant gender or racial predominance observed; average patient age was 60.

Related Experiment Videos

  • Abdominal pain and palpable mass were common presentations.
  • Small bowel mesentery was the most frequent site of involvement, presenting as a mass or diffuse thickening.
  • All cases showed fibrosis, chronic inflammation, and fat necrosis, often with mixed components.
  • Clinical and gross features did not reliably differentiate between ML, MP, and SM.
  • Of 39 patients followed postoperatively, none died from these lesions.

    • Conclusions:

    • ML, MP, and SM appear to be histologic variants of a single clinical entity.
    • "Sclerosing mesenteritis" is proposed as the most appropriate diagnostic term due to overlapping features.