Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interaction study between phenprocoumon and flurbiprofen

G A Marbet, F Duckert, M Walter

    Current Medical Research and Opinion
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Prosthetic heart valves and rare hypersensitivity to vitamin K antagonists resulting from factor IX mutation: how to manage anticoagulation?

    Haemophilia : the official journal of the World Federation of Hemophilia·2009
    Same author

    Unexpected bleeding following eyelid tumor resection leading to the rare diagnosis of acquired haemophilia.

    Klinische Monatsblatter fur Augenheilkunde·2008
    Same author

    Quantification of coagulation factors and inhibitors. Still a special task.

    Hamostaseologie·2006
    Same author

    [Heparins].

    Therapeutische Umschau. Revue therapeutique·2003
    Same author

    [Factor XIII in man: a review].

    Hamostaseologie·2002
    Same author

    Influence of the genetic background on platelet function, microparticle and thrombin generation in the common laboratory mouse.

    Platelets·2002
    Same journal

    Multidrug-resistant <i>Pseudomonas aeruginosa</i> in Jordan: epidemiology, trends, determinants, and clinical outcomes.

    Current medical research and opinion·2026
    Same journal

    RSV disease and vaccination knowledge, attitudes, and practices among US adults: a 2024-2025 RSV season survey.

    Current medical research and opinion·2026
    Same journal

    Clinical and healthcare resource utilization outcomes following revision knee arthroplasty with and without a gradually reducing radius revision knee system.

    Current medical research and opinion·2026
    Same journal

    Medication adherence measurement methods and their reported relationship with medication safety outcomes: a scoping review.

    Current medical research and opinion·2026
    Same journal

    BMI response to dapagliflozin with or without semaglutide across obesity classes: a real-world observational study conducted in Saudi Arabia.

    Current medical research and opinion·2026
    Same journal

    Comparative efficacy of tislelizumab + FOLFOX or CAPOX for gastric/gastroesophageal junction adenocarcinoma: an exploratory matching-adjusted indirect comparison.

    Current medical research and opinion·2026
    See all related articles

    Flurbiprofen shows minimal interference with phenprocoumon oral anticoagulation. Coagulation parameters were only moderately affected, suggesting no significant clinical relevance for patients on anticoagulation therapy.

    Area of Science:

    • Pharmacology
    • Hematology
    • Clinical Medicine

    Background:

    • Oral anticoagulants like phenprocoumon are crucial for preventing thromboembolic events.
    • Non-steroidal anti-inflammatory drugs (NSAIDs) such as flurbiprofen are commonly used for pain and inflammation.
    • Potential interactions between NSAIDs and anticoagulants require careful evaluation.

    Purpose of the Study:

    • To investigate the effects of flurbiprofen on coagulation and hemostasis parameters in patients receiving phenprocoumon.
    • To determine the clinical relevance of any observed changes in coagulation during concurrent use.

    Main Methods:

    • A study involving 19 patients on fixed-dose phenprocoumon.
    • Laboratory coagulation tests performed during a control period, during flurbiprofen administration (50 mg thrice daily for 2 weeks), and after cessation.

    Related Experiment Videos

  • Measurement of prothrombin time, Factor II, Factor X, Factor IX, phenprocoumon concentration, spontaneous platelet aggregation, and Ivy bleeding time.

    • Main Results:

    • Quantitative changes in coagulation parameters were moderate, with some reaching statistical significance.
    • Prothrombin time, Factor II, and Factor X values decreased; Factor IX decreased initially but normalized.
    • Phenprocoumon concentration, spontaneous platelet aggregation, and Ivy bleeding time remained largely unchanged or within normal limits.

    Conclusions:

    • Flurbiprofen demonstrates minimal interference with phenprocoumon-based oral anticoagulation.
    • Observed effects on coagulation and hemostasis are likely of no significant clinical relevance for patients on this regimen.