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Regulation of rat neuronal nitric oxide synthase activity by chronic alcoholization
M Naassila1, F Beauge, M Daoust
1INSERM U295, Université de Médecine Pharmacie, Saint Etienne du Rouvray, France.
Alcohol and Alcoholism (Oxford, Oxfordshire)
|January 1, 1997
Abstract:
Rat neuronal nitric oxide (NO) synthase (nNOS) activity was measured in frontal cortex, hippocampus, striatum and cerebellum using the assay of [3H]citrulline, following chronic alcoholization. The Km and Vmax values were significantly increased in the frontal cortex and in the striatum, and were not affected in the cerebellum and hippocampus.