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[Minor effect of anti-inflammatory therapy on intraocular inflammation after minimally invasive phacoemulsification]
1Universitäts-Augenklinik Giessen.
Unlabelled:
In a prospective study, we examined the influence of different anti-inflammatory treatments on intraocular inflammation after minimally invasive cataract surgery.
Patients And Methods:
A total of 150 patients (39-88 years of age) underwent phacoemulsification using a temporal clear-corneal tunnel incision and implantation of a 5-mm PMMA posterior chamber. Each patient was randomly assigned to one of the following 5 treatment groups, each consisting of 30 patients: (1) diclofenac 0.1% unconserved eyedrops (DICun) pre- and postoperatively; (2) diclofenac 0.1% conserved eyedrops (DICco) pre- and postoperatively; (3) DICun postoperatively; (4) DICun pre- and postoperatively, plus dexamethasone-21-dihydrogenphosphate 0.1% eyedrops (DEXA) postoperatively; (5) DEXA postoperatively. The aqueous flare was measured pre- and postoperatively using the laser flare-cell meter.
Results:
In group 1, the flare (in photon counts/ms) increased from 10.8 +/- 1.7 preoperatively to only 14.7 +/- 3.1 in the afternoon of the day of surgery. Even on day 1 postoperatively, the flare decreased to 9.3 +/- 0.9 and remained relatively constant on days 3 and 7 after surgery. There were no significant differences among the groups concerning flare means (P = 0.35) or time courses (P = 0.51).
Discussion:
Anti-inflammatory treatment had no significant influence on the amount of postoperative aqueous flare. This is because of the fact that clear corneal phacoemulsification per se leads to an extremely low intraocular inflammation and thus makes the importance of anti-inflammatory pharmacotherapy relative.
Insights
Different anti-inflammatory treatments did not significantly impact intraocular inflammation after minimally invasive cataract surgery. Clear corneal phacoemulsification itself results in minimal inflammation, reducing the need for anti-inflammatory drugs.
Area of Science:
- Ophthalmology
- Surgical Innovation
- Pharmacology
Background:
- Minimally invasive cataract surgery, specifically clear corneal phacoemulsification, is a common procedure.
- Postoperative intraocular inflammation is a concern following cataract surgery.
- The role of anti-inflammatory pharmacotherapy in managing this inflammation requires investigation.
Purpose of the Study:
- To evaluate the efficacy of various anti-inflammatory treatments in controlling intraocular inflammation after minimally invasive cataract surgery.
- To compare the effects of different topical anti-inflammatory agents and their administration timings.
Main Methods:
- A prospective study involving 150 patients undergoing phacoemulsification.
- Patients were randomized into five groups receiving different regimens of diclofenac and dexamethasone eyedrops.
- Intraocular inflammation was quantified by measuring aqueous flare using a laser flare-cell meter pre- and postoperatively.
Main Results:
- No significant differences in the mean aqueous flare or its time course were observed among the five treatment groups.
- Postoperative aqueous flare levels were consistently low across all groups.
- The observed inflammation levels were minimal regardless of the anti-inflammatory treatment administered.
Conclusions:
- Anti-inflammatory treatments demonstrated no significant influence on postoperative aqueous flare levels.
- Clear corneal phacoemulsification surgery inherently causes very low intraocular inflammation.
- The clinical significance of anti-inflammatory pharmacotherapy may be limited in the context of this surgical technique.