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Oxidative phosphorylation and F(O)F(1) ATP synthase activity of human hepatocellular carcinoma
1Institute of Medical Biochemistry and Chemistry, University of Bari, Italy.
Biochemistry and Molecular Biology International
|April 1, 1996
Abstract:
A study of mitochondrial oxidative phosphorylation in biopsies from human hepatocellular carcinoma is presented. Tumour mitochondria as compared to control liver mitochondria, besides a reduced activity of complex IV (cytochrome c oxidase) of the respiratory chain, show a decreased phosphorylative capacity. This appears to be mainly related to a defective F o F(1) ATP synthase complex. Use of an antibody against the F(1) portion of the complex demonstrate a definite decrease for the beta subunit of F(1) in tumour mitochondria.