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Potent antihepatotoxic activity of dicaffeoyl quinic acids from propolis
P Basnet1, K Matsushige, K Hase
1Research Institute for Wakan-Yaku (Traditional Sion-Japenese Medicines), Toyama Medicine and Pharmaceutical University, Japan.
Biological & Pharmaceutical Bulletin
|April 1, 1996
Abstract:
Hepatoprotective activity guided chemical analyses led to the isolation of two dicaffeoyl quinic acid derivatives, methyl 3,4-di-O-caffeoyl quinate (1) and 3,4-di-O-caffeoyl quinic acid (2) from water extract of propolis, and their structures were determined by the use of 2D NMR. These compounds were stronger antihepatotoxic agents than glycyrrhizin.