[Serum apolipoprotein B (apoB) in patients with hypothyroidism]

The concentrations of serum lipids (total cholesterol, triacylglycerols), apolipoprotein B and thyroid hormones (thyroxine, triiodthyronine) were observed before and during hormone replacement therapy by thyroid hormones in 24 hypothyroid patients (18 women and 6 men) until the state of euthyroidism was reached. The observed parameters regained standard values gradually, while the concentration of apolipoprotein B recovered to normal as the last among them. Therefore the authors recommend to consider apolipoprotein B concentration in serum as a risk factor of the development of arteriosclerosis in hypothyroid patients, the value of apolipoprotein B concentration can serve as a guideline in choosing the optimal hormone substitution therapy. (Tab. 1, Fig. 1, Ref. 5.).