Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

131I therapy for elevated thyroglobulin levels

M Schlumberger1, F Mancusi, E Baudin

  • 1Institut Gustave-Roussy Villejuif, France.

Thyroid : Official Journal of the American Thyroid Association
|April 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characteristics, management, and outcomes of patients with VIPoma-A retrospective analysis of the ENETS database.

Journal of neuroendocrinology·2026
Same author

Streptozotocin plus 5-fluorouracil followed by everolimus or the reverse sequence in patients with advanced pancreatic neuroendocrine tumors (SEQTOR-GETNE phase III study): a randomized clinical trial.

ESMO open·2025
Same author

Time-domain braiding of anyons.

Science (New York, N.Y.)·2025
Same author

Proof of concept and design of an externally controlled trial for patients with gastro-enteropancreatic neuroendocrine carcinomas based on the randomized phase II BEVANEC trial.

European journal of cancer (Oxford, England : 1990)·2025
Same author

Time-resolved sensing of electromagnetic fields with single-electron interferometry.

Nature nanotechnology·2025
Same author

Neuroendocrine neoplasms of head and neck, genitourinary and gynaecological systems, unknown primaries, parathyroid carcinomas and intrathyroid thymic neoplasms: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.

ESMO open·2024
Same journal

Stimulating Thyrotropin Receptor Antibodies Enhance the Expression of Both Thyrotropin Receptors and Insulin-Like Growth Factor 1 Receptors in Fibroblasts.

Thyroid : official journal of the American Thyroid Association·2026
Same journal

Mild Thyroid Eye Disease-The Most Common yet the Least Studied Presentation of Thyroid Eye Disease.

Thyroid : official journal of the American Thyroid Association·2026
Same journal

In Memoriam: Lawrence Crane Wood (1935-2026).

Thyroid : official journal of the American Thyroid Association·2026
Same journal

Trends in Management and Outcomes of Pediatric Hyperthyroidism Over Two Decades.

Thyroid : official journal of the American Thyroid Association·2026
Same journal

Targeted Therapy-Induced Erythrocytosis in Thyroid Cancers: An Underrecognized Safety Signal from a Retrospective Study.

Thyroid : official journal of the American Thyroid Association·2026
Same journal

<i>Retraction Notice:</i> High Iodine Concentration Attenuates <i>RET/PTC3</i> Oncogene Activation in Thyroid Follicular Cells.

Thyroid : official journal of the American Thyroid Association·2026
See all related articles

Higher doses of radioactive iodine (131I) can improve the detection of thyroid cancer metastases. This approach is recommended for patients with elevated thyroglobulin levels, aiding in early diagnosis and treatment planning for recurrent disease.

Area of Science:

  • Nuclear Medicine
  • Oncology
  • Endocrinology

Background:

  • Radioactive iodine (131I) is a cornerstone in the management of differentiated thyroid cancer.
  • Detecting low levels of residual disease or metastases can be challenging with standard diagnostic activities.

Purpose of the Study:

  • To evaluate the utility of higher therapeutic doses of 131I for detecting metastatic thyroid cancer.
  • To establish criteria for patient selection for this enhanced diagnostic approach.

Main Methods:

  • Administering a higher activity of 131I (100 mCi) for diagnostic scanning.
  • Analyzing post-therapy 131I total body scans for foci of uptake.
  • Correlating findings with thyroglobulin levels during and off L-Thyroxine (LT4) treatment.

Related Experiment Videos

Main Results:

  • A higher 131I activity significantly increases detection rates of metastases compared to diagnostic doses.
  • In 80% of selected patients (Tg > 5 ng/mL on LT4 or > 10 ng/mL off LT4), uptake foci were identified.
  • Low uptake in small metastases can lead to higher 131I concentration, improving detectability.

Conclusions:

  • Therapeutic doses of 131I are valuable for detecting otherwise undetectable thyroid cancer metastases.
  • Routine use in specific patient groups can guide further management, including surgery or alternative treatments.
  • Dosimetric considerations highlight the importance of 131I concentration over absolute uptake values.