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Standards for radioiodines

B M Coursey1

  • 1Ionizing Radiation Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.

Thyroid : Official Journal of the American Thyroid Association
|April 1, 1997
PubMed
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The National Institute of Standards and Technology provides essential radioactivity Standard Reference Materials (SRMs) for radioiodines. These materials ensure quality control in radiopharmaceutical manufacturing and accurate medical diagnostics.

Area of Science:

  • Metrology
  • Nuclear Science
  • Radiopharmaceutical Quality Control

Background:

  • The National Institute of Standards and Technology (NIST) is the primary standards laboratory for civilian technology in the United States.
  • NIST develops and maintains physical measurement standards crucial for medical diagnostics and therapy.
  • For five decades, NIST has been instrumental in providing radioactivity Standard Reference Materials (SRMs) for radioiodines.

Purpose of the Study:

  • To detail the methods used by NIST for standardizing radioiodine isotopes.
  • To highlight the availability and importance of NIST-developed radioactivity SRMs.
  • To underscore NIST's role in supporting the radiopharmaceutical industry's quality assurance.

Main Methods:

  • Standardization of Iodine-131 (131I) using 4 pi beta-gamma coincidence counting.

Related Experiment Videos

  • Standardization of Iodine-129 (129I) utilizing 4 pi beta-gamma anti-coincidence counting.
  • Employing 4 pi(e,x)-gamma coincidence counting for Iodine-123 (123I) and x-gamma sum peak coincidence counting for Iodine-125 (125I).
  • Calibration of dose calibrators and scintillation counters using NIST-standardized sources.

    • Main Results:

    • NIST has established robust methods for standardizing key radioiodine isotopes.
    • Radioiodine SRMs, including 131I and 125I, are available annually.
    • The long-lived 129I SRM has been reissued, ensuring continued availability.

    Conclusions:

    • NIST's radioactivity SRMs and standardization methods are vital for the radiopharmaceutical industry.
    • These resources ensure the accuracy and reliability of medical radioiodine products.
    • NIST's ongoing contributions support advancements in nuclear medicine and diagnostics.