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Delayed vs. immediate adverse reactions to ionic and non-ionic low-osmolality contrast media
H Oi1, H Yamazaki, M Matsushita
1Department of Radiology, Osaka Teishin Hospital, Japan.
Radiation Medicine
|January 1, 1997
Summary
Predicting delayed adverse reactions to contrast media is not possible based on allergy history or immediate reactions. Immediate reactions were more common with ioxaglate than iopamidol, but delayed reactions showed no significant difference between the two contrast agents.
Area of Science:
- Radiology
- Pharmacology
- Clinical Trials
Background:
- Adverse reactions to contrast media can be immediate or delayed.
- Low-osmolality ionic and non-ionic contrast media are commonly used in CT examinations.
- Understanding the correlation between immediate and delayed reactions is crucial for patient safety.
Purpose of the Study:
- To evaluate the correlation between immediate and delayed adverse reactions.
- To compare reactions between low-osmolality ionic (ioxaglate) and non-ionic (iopamidol) contrast media.
Main Methods:
- A comparative survey of 984 patients undergoing contrast-enhanced CT.
- Administration of ioxaglate to 472 patients and iopamidol to 512 patients.
- Recording immediate reactions and surveying delayed reactions via questionnaire.
Main Results:
- Immediate reactions were significantly lower with iopamidol (6.4%) than ioxaglate (23.9%).
- No statistically significant difference in delayed reactions between ioxaglate (16.5%) and iopamidol (14.9%).
- Delayed reactions occurred without immediate reactions in most cases for both contrast media.
Conclusions:
- Delayed adverse reactions to contrast media cannot be reliably predicted by immediate reactions or allergy history.
- Clinical decisions regarding contrast media should consider the low predictability of delayed reactions.