The anisotropic structure of the human left and right ventricles

An important determinant of cardiac output derives from the structure of the ventricular wall given by the arrangement of the cardiac muscle fibres. A key feature of this arrangement is both a global and local anisotropy. First, a preparation method necessary for analyzing the main aspects of spatial fibre architecture is outlined. Global anisotropy can be described by a gross band-like structure wrapping both left and right ventricles while local anisotropy results from the arrangement of the individual muscle fibres within the band. In pathologic cases this basic structure may be disturbed leading to cardiac failure. Second, a Finite Element model, formulated on the basis of Magnetic Resonance measurements has been devised which is intended to reflect the global as well as the local anisotropy of the ventricles in order to further the understanding of cardiac performance.