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Separation and quantitation of glycolipids as penetration modifiers in human skin using high-performance liquid
1Martin-Luther-University, Department of Pharmacy, Halle (Saale), Germany.
Journal of Chromatography. A
|April 4, 1997
Abstract:
An high-performance liquid chromatography-mass spectrometry method is presented for the measurement of glycolipids used as modulators of the penetration of drugs into human skin. In methanol extracts from different skin layers a detection limit of 100-400 pg/ml could be achieved. A routine analytical procedure could be set up with good quantitation reliability (relative standard deviation 6.6%).