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Related Experiment Videos

I.m. midazolam as premedication produces a concentration-dependent decrease in core temperature in male volunteers

T Matsukawa1, K Hanagata, M Ozaki

  • 1Department of Anaesthesia, Yamanashi Medical University, Japan.

British Journal of Anaesthesia
|April 1, 1997
PubMed
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Intramuscular midazolam (intramuscular) reduces core body temperature in a dose-dependent manner. This effect is linked to impaired thermoregulatory vasoconstriction, leading to heat redistribution.

Area of Science:

  • Anesthesiology and Pharmacology
  • Thermoregulation and Physiology

Background:

  • Midazolam is a common anesthetic agent.
  • Its effects on core body temperature require further investigation.

Purpose of the Study:

  • To investigate the dose-dependent effect of intramuscular midazolam on core body temperature.
  • To explore the relationship between midazolam dosage, sedation levels, and thermoregulation.

Main Methods:

  • A randomized, controlled study involving six male volunteers.
  • Administration of intramuscular midazolam at doses of 0.025 mg/kg and 0.075 mg/kg, with a control day.
  • Core body temperature measured via tympanic membrane; skin temperature and perfusion assessed using surface probes and gradients.
  • Sedation levels evaluated 30 minutes post-administration.

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Main Results:

  • A significant decrease in tympanic membrane temperature was observed at 20 and 30 minutes after the higher midazolam dose (0.075 mg/kg).
  • The reduction in core temperature correlated with increased sedation levels.
  • Intramuscular midazolam demonstrated a concentration-dependent decrease in tympanic membrane temperature.

Conclusions:

  • Intramuscular midazolam administration impairs tonic thermoregulatory vasoconstriction.
  • This impairment facilitates core-to-peripheral heat redistribution in a dose-dependent manner.
  • Midazolam's impact on body temperature is a significant consideration in clinical practice.