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T2 relaxation time of bone marrow water and lipid: correlation with serum ferritin in normal individuals
H Ishijima1, H Ishizaka, J Aoki
1Department of Diagnostic Radiology, Gunma University Hospital, Japan.
Purpose:
This study investigated the correlation between the iron content of bone marrow and the transverse relaxation times (T2 values) of bone marrow water and lipid on MRI.
Method:
The T2 of the water and lipid fractions of bone marrow was selectively measured in the L1-3 vertebral bodies using the chemical shift misregistration effect on MRI. Results were compared to the serum ferritin levels in 27 healthy subjects.
Results:
The 1/T2 of the water fraction ws strongly correlated with the serum ferritin, but there was no correlation between the 1/T2 of the lipid fraction and serum ferritin.
Conclusion:
Selective T2 measurement of the water fraction in bone marrow allows precise estimation of the marrow iron content.