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Related Experiment Videos

Insulin and cognitive function in an elderly population. The Rotterdam Study

R P Stolk1, M M Breteler, A Ott

  • 1Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands. stolk@epib.fgg.eur.nl

Diabetes Care
|May 1, 1997
PubMed
Summary

Higher serum insulin levels are linked to poorer cognitive function and dementia risk in women. This suggests a potential direct impact of insulin on the brain, not solely through cardiovascular factors.

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Gerontology

Background:

  • Insulin plays a crucial role in brain function, including glucose metabolism and neurotransmission.
  • Dysregulation of insulin signaling has been implicated in cognitive decline and neurodegenerative diseases.

Purpose of the Study:

  • To investigate the association between serum insulin levels and cognitive function in an elderly population.
  • To explore potential sex differences in this relationship.

Main Methods:

  • The Rotterdam Study cohort included 5,510 participants aged 55 years and older.
  • Serum insulin was measured 2 hours post-oral glucose load; cognitive function assessed using the Mini Mental State Examination.

Main Results:

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  • Increased postload insulin levels were significantly associated with decreased cognitive function in women (age-adjusted regression coefficient -0.10 per 50 mU/l insulin).
  • This association persisted across subgroups, including women with and without cardiovascular disease, and after excluding individuals with diabetes.
  • Women with dementia exhibited higher mean insulin levels compared to controls.

    • Conclusions:

    • Elevated serum insulin may be a risk factor for cognitive decline and dementia specifically in women.
    • The findings support a potential direct effect of insulin on the brain, independent of traditional cardiovascular risk factors.