Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Studies on bone ion exchanges using multiple-tracer indicator-dilution techniques

P J Kelly, J B Bassingthwaighte

    Federation Proceedings
    |November 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Diverse Data Sets Can Yield Reliable Information through Mechanistic Modeling: Salicylic Acid Clearance.

    British journal of pharmaceutical research·2016
    Same author

    Left ventricular finite element model bounded by a systemic circulation model.

    Journal of biomechanical engineering·2013
    Same author

    BIFURCATING DISTRIBUTIVE SYSTEM USING MONTE CARLO METHOD.

    Mathematical and computer modelling·2012
    Same author

    Evaluating maximum likelihood estimation methods to determine the Hurst coeficient.

    Physica A·2012
    Same author

    The spectra and periodograms of anti-correlated discrete fractional Gaussian noise.

    Physica A·2012
    Same author

    The kinetics of Ca-Na exchange in excitable tissue.

    Mathematical biosciences·2011
    Same journal

    ASBESTOS FIBERS MEDIATE THE UPTAKE OF DNA INTO PRIMATE CELLS IN CULTURE.

    Federation proceedings·2018
    Same journal

    Chemical protection of mammalian tissues.

    Federation proceedings·2014
    Same journal

    Dietary requirements for fertility and lactation; dried yeasts as sources of proteins and vitamin B complex for growth, reproduction and lactation.

    Federation proceedings·2010
    Same journal

    On the mode of action of chlorinating compounds.

    Federation proceedings·2010
    Same journal

    d-Amino acid oxidase of Proteus morganii.

    Federation proceedings·2010
    Same journal

    Studies on thymus nucleohistone.

    Federation proceedings·2010
    See all related articles

    Bone capillary transport of ions and large molecules like diphosphonates occurs via passive diffusion. This suggests that the cellular processes within bone, not the capillaries, control ion and molecule distribution.

    Area of Science:

    • Bone biology and physiology
    • Capillary transport mechanisms
    • Radiopharmaceutical biodistribution

    Background:

    • Bone is a dynamic tissue with significant ion and molecule exchange.
    • Understanding transcapillary movement is crucial for bone-related therapies and diagnostics.
    • Previous studies suggest passive diffusion plays a role in bone substance transport.

    Purpose of the Study:

    • To elucidate the primary mechanism of ion and large molecule transport across bone capillaries.
    • To investigate the role of molecular size in transcapillary passage.
    • To determine if capillary exchange is passive and infer the site of ion partitioning.

    Main Methods:

    • Indicator-dilution method to assess instantaneous fractional escape.
    • Analysis of transcapillary movement for ions (e.g., 85Sr) and large molecules (99mTc-labeled EHDP, 99mTc-labeled pyrophosphate).

    Related Experiment Videos

  • Comparison of extraction rates based on molecular size and properties.

    • Main Results:

    • Free diffusion is the principal mechanism for ion movement across bone capillaries.
    • Large molecules (diphosphonates) also move via passive diffusion but exhibit lower extraction rates due to size limitations.
    • Extraction rates correlate inversely with molecular size, impacting passage through transcapillary clefts.

    Conclusions:

    • Transcapillary exchange in bone is primarily a passive diffusion process.
    • The size of molecules significantly influences their extraction rate across bone capillaries.
    • Ion and molecule partitioning in bone is likely controlled by cellular processes beyond the capillary level.