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Risperidone in adolescents with schizophrenia: an open pilot study

J L Armenteros1, A H Whitaker, M Welikson

  • 1College of Physicians and Surgeons, Columbia University, New York, USA.

Journal of the American Academy of Child and Adolescent Psychiatry
|May 1, 1997
PubMed
Summary

Risperidone effectively treated schizophrenia symptoms in adolescents. This open pilot study found significant symptom improvement with no major adverse effects, indicating good tolerability in young patients.

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Area of Science:

  • Child and Adolescent Psychiatry
  • Pharmacology
  • Schizophrenia Treatment

Background:

  • Schizophrenia affects adolescents, necessitating effective and safe treatment options.
  • Risperidone is an atypical antipsychotic with potential for treating adolescent schizophrenia.

Purpose of the Study:

  • To evaluate the short-term efficacy and safety of risperidone in adolescents diagnosed with schizophrenia.
  • To assess risperidone's impact on core schizophrenia symptoms in a young population.

Main Methods:

  • An open-label pilot study involving 10 adolescents (11-18 years) with schizophrenia.
  • A 6-week treatment period with risperidone after a 2-week medication washout.
  • Dosage individually adjusted up to 10 mg/day, with symptom assessment using standardized scales.

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Main Results:

  • Significant improvements were observed in Positive and Negative Syndrome Scale for Schizophrenia (PANSS) scores.
  • Statistically significant reductions in symptoms were noted on the Brief Psychiatric Rating Scale (BPRS) and Clinical Global Impression (CGI).
  • Risperidone was well-tolerated, with no major adverse reactions reported during the study.

Conclusions:

  • Risperidone demonstrated short-term efficacy in reducing schizophrenia symptoms among adolescents.
  • The medication was well-tolerated in this adolescent sample, suggesting a favorable safety profile.