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Case study: risperidone-induced hepatotoxicity in pediatric patients

S Kumra1, D Herion, L K Jacobsen

  • 1Department of Child Psychiatry, NIMH, Bethesda, MD 20892-1600, USA. kumra@helix.nih.gov

Journal of the American Academy of Child and Adolescent Psychiatry
|May 1, 1997
PubMed
Summary

Long-term risperidone use in children may cause liver damage, particularly in males. Discontinuation of the drug and weight loss reversed the observed hepatotoxicity.

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Area of Science:

  • Pediatric Psychiatry
  • Hepatology
  • Pharmacovigilance

Background:

  • Risperidone is an atypical antipsychotic used in pediatric populations.
  • Long-term use necessitates understanding potential adverse effects.
  • Hepatic adverse events require careful documentation in children.

Observation:

  • A case study reviewed pediatric patients treated with risperidone.
  • Two male pediatric patients exhibited obesity, liver enzyme abnormalities, and fatty liver.
  • These adverse effects were documented in patients admitted to the National Institute of Mental Health (NIMH).

Findings:

  • Long-term risperidone therapy was associated with hepatotoxicity in two male pediatric patients.
  • Evidence of fatty liver and elevated liver enzymes were observed.

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  • Liver damage resolved upon risperidone discontinuation and/or weight loss.

    • Implications:

    • Pediatric patients on long-term risperidone require baseline and periodic liver function tests.
    • Monitoring weight gain during risperidone therapy is crucial.
    • This suggests a potential link between risperidone, obesity, and liver injury in pediatric males.