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Related Experiment Video

Updated: Jul 13, 2026

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

Microsatellite instability in colorectal adenomas

W S Samowitz¹, M L Slattery

¹Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, USA.

Gastroenterology

|May 1, 1997

Summary

Microsatellite instability is rare in colon adenomas, unlike in colon cancers. This suggests that microsatellite instability is not an early event in the development of most colorectal cancers.

Area of Science:

Gastroenterology
Oncology
Genetics

Background:

Microsatellite instability (MSI) in sporadic colon cancers, especially right-sided ones, is linked to acquired mismatch repair defects.
The role of MSI as an early event in the adenoma-carcinoma sequence remains unclear.

Purpose of the Study:

To investigate microsatellite instability (MSI) in colonic adenomatous polyps.
To determine if MSI is an early genetic event in the development of colorectal neoplasia.

Main Methods:

Analysis of 93 sporadic colonic adenomas (44 right-sided, 49 left-sided) from 48 individuals.
Evaluation of microsatellite instability using 10 polymerase chain reaction primer sets.

Main Results:

The vast majority of adenomas (80%) exhibited no microsatellite instability (MSI).

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Nearly all adenomas (98%) showed instability with less than 30% of primer sets.

No significant difference in MSI prevalence was observed between right-sided and left-sided adenomas, except for one case.

Conclusions:

Colonic adenomas display significantly lower levels of microsatellite instability (MSI) compared to colon carcinomas.
The right-sided predominance of MSI seen in colon cancers is not present in adenomas.
Microsatellite instability is generally not an early event in the progression of colonic neoplasia.