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Related Experiment Videos

Asthma: how early to start using inhaled steroids?

V Madden

    Professional Care of Mother and Child
    |January 1, 1997
    PubMed
    Summary

    Early intervention with inhaled steroids in new asthma cases may improve lung function. The START study investigates this concept in children and adults, aiming to prevent irreversible lung damage.

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    Area of Science:

    • Pulmonology
    • Pediatric Asthma Management
    • Clinical Trials

    Background:

    • Inhaled corticosteroids are standard for moderate-to-severe asthma.
    • The early intervention concept aims to prevent irreversible lung damage by initiating treatment promptly.
    • Current medical opinion is divided on the justification of very early inhaled steroid use, especially in children.

    Purpose of the Study:

    • To investigate the effectiveness of early intervention with inhaled steroids in newly-diagnosed asthmatics.
    • To gather evidence on the optimal timing for initiating inhaled steroid treatment.
    • To assess the impact of early intervention on lung function and growth in children.

    Main Methods:

    • The START study is a large-scale, international clinical trial.
    • Involves nearly 7,000 patients aged 6-60 years with newly diagnosed asthma.
    • Data collection spans 32 countries.

    Main Results:

    • A prior Danish study suggests early intervention in children improves lung function.
    • No significant adverse effects on growth rate were observed in children in the Danish study.
    • The START study will provide further evidence on the benefits and risks of early intervention.

    Conclusions:

    • Early intervention with inhaled steroids is a potential strategy for managing newly diagnosed asthma.
    • Further evidence from the START study is needed to confirm optimal treatment timing.
    • The findings will inform clinical guidelines for pediatric and adult asthma management.

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