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Updated: Jul 13, 2026

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI)
Published on: November 27, 2019
Decreased anterior cingulate gyrus metabolic rate in schizophrenia
M M Haznedar1, M S Buchsbaum, C Luu
1Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029-6574, USA.
Objective:
This study examined glucose metabolism in the anterior and posterior cingulate cortex in schizophrenia.
Method:
Fifty unmedicated male schizophrenic patients and 24 normal men were studied with positron emission tomography.
Results:
Compared with the normal men, the schizophrenic patients had lower relative metabolic rates in the anterior cingulate and higher rates in the posterior cingulate.
Conclusions:
The findings suggest hypofunction in the anterior cingulate cortex in schizophrenia.
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