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[Hepatitis E virus infection. Hepatitis outbreaks]

¹Service d'Hépatologie, Hôpital Beaujon, Clichy. erlinger@bichat.inserm.fr

Presse Medicale (Paris, France : 1983)

|March 22, 1997

Summary

Hepatitis E virus (HEV) is a non-enveloped virus causing large outbreaks via contaminated water. HEV infection can lead to severe hepatitis, especially in pregnant women, but new vaccines show promise for prevention.

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Area of Science:

Virology
Hepatology
Public Health

Context:

Hepatitis E virus (HEV) is a non-enveloped virus with a single-stranded RNA genome.
HEV is transmitted via the fecal-oral route, primarily through contaminated drinking water.
Large outbreaks are common in developing regions, posing significant public health challenges.

Purpose:

To provide an overview of the Hepatitis E virus.
To highlight transmission routes and disease characteristics.
To discuss diagnostic methods and future prevention strategies.

Summary:

HEV is a non-enveloped virus (32-34 nm) with a 7.5 kb RNA genome.
Transmission occurs through contaminated water, leading to large outbreaks globally.
Fulminant hepatitis occurs in 0.5-3% of cases, rising to 15-25% in pregnant women, with frequent vertical transmission.

Impact:

ELISA tests can detect IgG and IgM antibodies for diagnosis.
Recombinant vaccines are under development, showing promise for efficient future prevention of HEV infections.

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