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Membrane permeability transition as induced by dysfunction of the electron transport chain
E Chávez1, E Meléndez, C Zazueta
1Departamento de Bioquímica Instituto Nacional de Cardiología, Ignacio Chávez, México, D.F., México.
Biochemistry and Molecular Biology International
|April 1, 1997
Abstract:
The results in this paper indicate that mitochondrial permeability transition is activated by dysfunction of the respiratory chain caused by anaerobiosis, exhaustion of the oxidative substrate, and antimycin A, in the presence of 100 microM Ca2+. Membrane damage coincides with the collapse of the electric gradient. The opening of the non-selective pore is prevented by cyclosporin A.