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[Study of the susceptibility of Staphylococcus sp. and Enterococcus sp. to teicoplanin and vancomycin]
I Mimica1, C M Mendes, L Mimica
1Faculdade de Ciências Médicas da Santa Casa de São Paulo.
Purpose:
The study was performed in order to evaluate the susceptibility of Enterococcus and Staphylococcus to teicoplanin and vancomycin.
Methods:
150 Enterococcus strains and 450 Staphylococcus strains (298 Staphylococcus aureus and 152 negative coagulase strains) isolated in three Brazilian hospitals were studied. The MICs were determined using teicoplanin and vancomycin E Test strips. The range of the antimicrobial concentration in each strip went from 256 mcg/mL to 0.016 mcg/mL. Diffusion tests using disks impregnated with 10 mcg of teicoplanin and 30 mcg of vancomycin were also performed.
Results:
All the 298 Staphylococcus aureus strains were susceptible to the two antimicrobials. Three of the 152 negative coagulase strains presented intermediate susceptibility to teicoplanin (MICs between 8 and 16 mcg/mL). Four of the 150 Enterococcus strains presented intermediate susceptibility to vancomycin but were totally susceptible to teicoplanin.
Conclusion:
According to these results teicoplanin and vancomycin are good therapeutical options in the treatment of staphylococcal and enterococcal infections.
Insights
Teicoplanin and vancomycin show high effectiveness against Staphylococcus aureus and Enterococcus strains. Some coagulase-negative Staphylococcus strains exhibited intermediate susceptibility to teicoplanin.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Context:
- Antibiotic resistance is a growing global health concern.
- Enterococcus and Staphylococcus species are common causes of hospital-acquired infections.
- Evaluating antimicrobial susceptibility is crucial for effective treatment strategies.
Purpose:
- To assess the in vitro susceptibility of Enterococcus and Staphylococcus isolates to teicoplanin and vancomycin.
- To compare the efficacy of teicoplanin and vancomycin against these bacterial pathogens.
- To identify potential resistance patterns in Brazilian hospital settings.
Summary:
- 150 Enterococcus and 450 Staphylococcus strains (including S. aureus and coagulase-negative staphylococci) were tested.
- Minimum Inhibitory Concentrations (MICs) were determined using E Test strips and disk diffusion assays.
- All S. aureus strains were susceptible; some coagulase-negative staphylococci showed intermediate teicoplanin susceptibility, and some Enterococcus strains showed intermediate vancomycin susceptibility.
Impact:
- Teicoplanin and vancomycin are confirmed as effective therapeutic options for staphylococcal and enterococcal infections.
- The study provides valuable data on antimicrobial resistance patterns in Brazil.
- Findings support the continued use of these antibiotics while highlighting the need for ongoing surveillance.