[Simvastatin and pregnancy]

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Updated: Nov 2, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

C Freyssinges1, M B Ducrocq

  • 1Laboratoires MSD-Chibret, Paris.

Therapie
|September 1, 1996
PubMed

This study concerns 169 women whose exposure to simvastatin (Zocor or Lodales) during pregnancy led to a request for information from pharmaceutical firms. The evolution of pregnancies (among which 2 were twins) was documented in 125 women: 66 women gave birth to normal babies, 40 requested and induced abortion, 12 spontaneous abortions occurred, and the 9 other known pregnancy issues were 4 premature newborns, 3 newborns with malformations and 2 fetal deaths. Apart from the 5 retrospective files concerning 5 spontaneous abortions, all the files were analysed prospectively. Except for induced abortions, regarding the prospective files, the pregnancy outcome was comparable with that of a general population.

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